Verbesserung der überlebensrate von dialysepatienten durch aktives vitamin D

Translated title of the contribution: Improving survival of dialysis patients with active vitamin D

M. Wolf*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiovascular disease is the leading cause of death among patients on hemodialysis. Secondary hyperparathyroidism (sHPT), hyperphosphatemia, hypocalcemia and deficiency of calcitriol, the active hormonal form of vitamin, are common complications of chronic kidney disease (CKD) that are associated with cardiovascular disease and mortality on dialysis. Treatment of sHPT using calcitriol or one of its analogs has traditionally focused on protection from bone complications, but several recent observational studies suggest a survival benefit of vitamin D therapy. While these results require verification in randomized trials and the potential biological mechanisms that underlie the benefit of vitamin D on dialysis survival require further study, several clues have recently emerged. Vitamin D exerts a variety of effects on the cardiovascular and immune systems, on inflammation, glucose tolerance, among others such that deficiencies in the vitamin D axis are associated with increased risk of adverse outcomes. Indeed, in recent work from our group, deficiencies in the vitamin D axis were associated with early mortality among incident hemodialysis patients regardless of serum PTH. These results suggest that critical deficiencies in the vitamin D axis are novel risk factors for cardiovascular disease and mortality which might explain why active vitamin D therapy improves survival, similarly independent of PTH levels.

Translated title of the contributionImproving survival of dialysis patients with active vitamin D
Original languageGerman
Pages (from-to)224-228
Number of pages5
JournalNieren- und Hochdruckkrankheiten
Volume37
Issue number5
StatePublished - May 1 2008

Keywords

  • Alfacalcidol
  • Deficiency of vitamin D
  • Hyperphosphatemia
  • Hypocalcemia
  • Incident hemodialysis patients
  • Mortality (total and cardiovascular)
  • Paricalcitol
  • Secondary hyperparathyroidism
  • Survival benefit of vitamin D therapy
  • Vitamin D analogs

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

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