Impulsive aggression in personality disorder correlates with platelet 5-HT(2A) receptor binding

Emil F. Coccaro*, Richard J. Kavoussi, Yvette I. Sheline, Mitchell E. Berman, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


The purpose of this study was to examine the relationship between platelet 5-HT(2A) receptor binding and aggressive behavior. 125I-LSD B(max) and K(d) values were measured for 22 subjects meeting DMS-III-R criteria for one or more personality disorders and 12 healthy volunteer subjects. Aggression and impulsivity were assessed using the Buss-Durkee Hostility Inventory (BDHI) Assault scale, Life History of Aggression (LHA) scale, and the Barratt-11 Impulsiveness scale (BIS-11). B(max) and K(d) values did not differ between personality-disordered subjects and healthy volunteers. However, both B(max) and K(d) values correlated positively with BDHI Assault scores in personality disordered subjects but not in healthy volunteer subjects. These results suggest that assaultiveness in personality-disordered subjects may covary with increasing numbers, but decreasing affinity, of platelet 5-HT(2A) receptor sites labeled by 125I-LSD.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
Issue number3
StatePublished - Mar 1997


  • aggression
  • platelet 5-HT(2A) receptor
  • serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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