Imputation methods for temporal radiographic texture analysis in the detection of periprosthetic osteolysis

Joel R. Wilkie*, Maryellen L. Giger, Lorenzo L. Pesce, Charles A. Engh, Robert H. Hopper, John M. Martell

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Periprosthetic osteolysis is a disease triggered by the body's response to tiny wear fragments from total hip replacements (THR), which leads to localized bone loss and disappearance of the trabecular bone texture. We have been investigating methods of temporal radiographic texture analysis (tRTA) to help detect periprosthetic osteolysis. One method involves merging feature measurements at multiple time points using an LDA or BANN. The major drawback of this method is that several cases do not meet the inclusion criteria because of missing data, i.e., missing image data at the necessary time intervals. In this research, we investigated imputation methods to fill in missing data points using feature averaging, linear interpolation, and first and second order polynomial fitting. The database consisted of 101 THR cases with full data available from four follow-up intervals. For 200 iterations, missing data were randomly created to simulate a typical THR database, and the missing points were then filled in using the imputation methods. ROC analysis was used to assess the performance of tRTA in distinguishing between osteolysis and normal cases for the full database and each simulated database. The calculated values from the 200 iterations showed that the imputation methods produced negligible bias, and substantially decreased the variance of the AUC estimator, relative to excluding incomplete cases. The best performing imputation methods were those that heavily weighted the data points closest to the missing data. The results suggest that these imputation methods appear to be acceptable means to include cases with missing data for tRTA.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationComputer-Aided Diagnosis
EditionPART 1
StatePublished - 2007
EventMedical Imaging 2007: Computer-Aided Diagnosis - San Diego, CA, United States
Duration: Feb 20 2007Feb 22 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 1
ISSN (Print)1605-7422


ConferenceMedical Imaging 2007: Computer-Aided Diagnosis
CountryUnited States
CitySan Diego, CA


  • Computer-aided diagnosis
  • Orthopedics
  • Temporal trends
  • Texture

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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