In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care

Luca Ciaffoni; David P. O’Neill; John H. Couper; Grant A.D. Ritchie; Gus Hancock; Peter A. Robbins

doi:10.1126/sciadv.1600560

In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care

Luca Ciaffoni^*, David P. O’Neill, John H. Couper, Grant A.D. Ritchie, Gus Hancock, Peter A. Robbins

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O₂, CO₂, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O₂ consumption by direct integration over time of the product of O₂ concentration and flow. The precision is illustrated by integrating the balance gas (N₂ plus Ar) flow and showing that this exchange was near zero. Measured O₂ consumption changed by <5% between air and O₂ breathing. Clinical capability was illustrated by recording O₂ consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O₂ consumption for intubated patients in critical care possible.

Original language	English (US)
Article number	e1600560
Journal	Science Advances
Volume	2
Issue number	8
DOIs	https://doi.org/10.1126/sciadv.1600560
State	Published - Aug 2016

Funding

We thank K. Valentine, P. Hurst, and T. Pragnell for the invaluable help on the electronics and software development. We would also like to thank M. Frise, K. Dorrington, J. Griffiths, K. Pattinson, and D. Young for their kind assistance in our early clinical studies. This work was funded by a Medical Research Council Discipline Hopping Award, the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Programme, and a Medical Research Council DPFS (Development Pathway Funding Scheme) Award. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.

ASJC Scopus subject areas

General

Access to Document

10.1126/sciadv.1600560

Cite this

@article{30f6782404124c619faf985e076d02ca,

title = "In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care",

abstract = "There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O2 consumption by direct integration over time of the product of O2 concentration and flow. The precision is illustrated by integrating the balance gas (N2 plus Ar) flow and showing that this exchange was near zero. Measured O2 consumption changed by <5% between air and O2 breathing. Clinical capability was illustrated by recording O2 consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O2 consumption for intubated patients in critical care possible.",

author = "Luca Ciaffoni and O{\textquoteright}Neill, {David P.} and Couper, {John H.} and Ritchie, {Grant A.D.} and Gus Hancock and Robbins, {Peter A.}",

note = "Publisher Copyright: 2016 {\textcopyright} The Authors.",

year = "2016",

month = aug,

doi = "10.1126/sciadv.1600560",

language = "English (US)",

volume = "2",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "8",

}

TY - JOUR

T1 - In-airway molecular flow sensing

T2 - A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care

AU - Ciaffoni, Luca

AU - O’Neill, David P.

AU - Couper, John H.

AU - Ritchie, Grant A.D.

AU - Hancock, Gus

AU - Robbins, Peter A.

PY - 2016/8

Y1 - 2016/8

N2 - There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O2 consumption by direct integration over time of the product of O2 concentration and flow. The precision is illustrated by integrating the balance gas (N2 plus Ar) flow and showing that this exchange was near zero. Measured O2 consumption changed by <5% between air and O2 breathing. Clinical capability was illustrated by recording O2 consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O2 consumption for intubated patients in critical care possible.

AB - There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O2 consumption by direct integration over time of the product of O2 concentration and flow. The precision is illustrated by integrating the balance gas (N2 plus Ar) flow and showing that this exchange was near zero. Measured O2 consumption changed by <5% between air and O2 breathing. Clinical capability was illustrated by recording O2 consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O2 consumption for intubated patients in critical care possible.

UR - http://www.scopus.com/inward/record.url?scp=84985888879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84985888879&partnerID=8YFLogxK

U2 - 10.1126/sciadv.1600560

DO - 10.1126/sciadv.1600560

M3 - Article

C2 - 27532048

AN - SCOPUS:84985888879

SN - 2375-2548

VL - 2

JO - Science Advances

JF - Science Advances

IS - 8

M1 - e1600560

ER -

In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this