Abstract
Aims: To determine if in vitro production of IL-22 and IL-17 correlated with resolution of HCV infection. Materials & methods: Human peripheral blood cells isolated from a well-defined cohort of resolved and chronic HCV-infected subjects were used to measure HCV-, influenza- and mitogen-activated T-cell proliferation. In addition, IL-22 and IL-17 production was measured via ELISAs and flow cytometry. Results: Resolved HCV subjects had a significantly higher T-cell proliferative response to recombinant NS3 protein compared with chronic HCV subjects. Resolved subjects had a dose-dependent IL-22 response to recombinant NS3 compared with chronic HCV subjects. Conclusion: IL-22 production is associated with antigen-specific induction of CD4 + T cells in individuals that resolved HCV infection, suggesting a potential role for IL-22 in HCV clearance.
Original language | English (US) |
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Pages (from-to) | 719-728 |
Number of pages | 10 |
Journal | Future Virology |
Volume | 7 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2012 |
Keywords
- IL-17
- IL-22
- T cell
- hepatitis C virus
- human PBMC
ASJC Scopus subject areas
- Virology