In-hospital pneumococcal polysaccharide vaccination is associated with detection of pneumococcal vaccine serotypes in adults hospitalized for community-acquired pneumonia

Carlos G. Grijalva*, Richard G. Wunderink, Yuwei Zhu, Derek J. Williams, Robert Balk, Sherene Fakhran, D. Mark Courtney, Evan J. Anderson, Chao Qi, Christopher Trabue, Andrew T. Pavia, Matthew R. Moore, Seema Jain, Kathryn M. Edwards, Wesley H. Self

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

During an etiology study of adults hospitalized for pneumonia, in which urine specimens were examined for serotypespecific pneumococcal antigen detection, we observed that some patients received 23-valent pneumococcal polysaccharide vaccine before urine collection. Some urine samples became positive for specific vaccine pneumococcal serotypes shortly after vaccination, suggesting false-positive test results.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2015

Keywords

  • Antigen
  • Pneumococcal conjugate vaccine
  • Pneumonia
  • Serotype
  • Urine

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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