In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance

Bernd H. Zinselmeyer, John Dempster, Alison M. Gurney, David Wokosin, Mark Miller, Hsiang Ho, Owain R. Millington, Karen M. Smith, Catherine M. Rush, Ian Parker, Michael Cahalan*, James M. Brewer, Paul Garside

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo. We have therefore tracked such cells in real time, in situ during the induction of oral priming versus oral tolerance. There were marked contrasts with respect to rate and type of movement and clustering between naive T cells and those exposed to antigen in immunogenic or tolerogenic forms. However, the major difference when comparing tolerized and primed T cells was that the latter formed larger and longerlived clusters within mucosal and peripheral lymph nodes. This is the first comparison of the behavior of antigen-specific CD4+ T cells in situ in mucosal and systemic lymphoid tissues during the induction of priming versus tolerance in a physiologically relevant model in vivo. JEM

Original languageEnglish (US)
Pages (from-to)1815-1823
Number of pages9
JournalJournal of Experimental Medicine
Volume201
Issue number11
DOIs
StatePublished - Jun 6 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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