In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana

Kathleen M. Powis*, Laura Smeaton, Michael D. Hughes, Esther A. Tumbare, Sajini Souda, Jennifer Jao, Kathleen E. Wirth, Joseph Makhema, Shahin Lockman, Wafaie Fawzi, Max Essex, Roger L. Shapiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Objective: To assess associations between in-utero triple antiretrovirals (cART) versus zidovudine (ZDV) monotherapy exposure and growth among HIV-uninfected children of HIV-infected women in Botswana. Design: Secondary retrospective data analysis from two randomized intervention trials of mother-to-child HIV transmission prevention. Methods: The Mashi and Mma Bana studies enrolled HIV-infected pregnant women, following their children through 24 months of age. This analysis includes singleton, fullterm, HIV-exposed uninfected children. Mothers received cART or ZDV at least 2 weeks predelivery, and breastfed up to 6 months. Weight-for-age (WAZ), length-for-age (LAZ) and weight-for-length (WLZ) z-scores were derived. Mean z-scores were compared by exposure group at 24 months (t-test, linear regression). Results: Of 819 children, 303 were ZDV-and 516 cART-exposed in utero. Maternal median enrolment CD4 was higher among ZDV versus cART-treated mothers (393 versus 324 cells/ml; P<0.0001). Median duration of antepartum antiretroviral use was shorter among ZDV-treated women (5.7 versus 12.0 weeks; P<0.0001). Median months breastfed were similar (5.9 and 6.0; P=0.43). At 24 months, mean LAZ and WAZwere significantly lower among cART-exposed children (LAZ-1.01 versus-0.74; P=0.003) (WAZ-0.53 versus-0.30; P=0.002) in unadjusted analyses. Adjusting for maternal CD4, viral load, enrolment site and maternal anthropometric measures, cART-exposed children had significantly lower LAZ and WAZ at 24 months (P=0.0004 for both). Conclusion: At 24 months, in-utero cART-exposed children had significantly lower LAZ and WAZ. Poor growth impacts childhood and adult mortality. These findings raise concerns for potential lasting health impacts among HIV-exposed uninfected children with in-utero cART exposure.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalAIDS
Volume30
Issue number2
DOIs
StatePublished - Jan 1 2016

Keywords

  • Growth
  • HIV-exposed uninfected infants
  • in-utero triple antiretrovirals

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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