In Vitro Activity of RP 59500 (quinupristin/dalfopristin) and Ramoplanin against Vancomycin-Resistant Enterococcus faecium

Tracey A. Ristow, Gary A Noskin, John R. Warren, Lance R. Peterson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Vancomycin-resistant Enterococcus faecium (VREF) collected between July 1991 and February 1994 were tested in vitro against RP 59500 and ramoplanin using agar dilution and standard macro broth dilution procedures. Colony counts were determined at 0, 4, and 24 h. RP 59500 had an MIC range of ≤0.5–8 μg/ml with an MIC90 of 2 μg/ml and a MBC range of ≤0.5–16 μg/ml with an MBC90 of 16 μg/ml. Ramoplanin had an MIC range of ≤0.125–1 μg/ml with an MBC range of ≤0.125–4 μg/ml. The MIC90 for ramoplanin was 1 μg/ml and the MBC90 was 4 μg/ml for the tested isolates. Against these isolates of E. faecium, RP 59500 was bactericidal at 8× MIC, a potentially achievable level using a high drug dosage.10 Ramoplanin was bactericidal at 2× MIC.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalMicrobial Drug Resistance
Volume1
Issue number4
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

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