In vitro and in vivo characterization of various ferrites for hyperthermia in cancer-treatment

D. H. Kim*, S. H. Lee, K. N. Kim, K. M. Kim, I. B. Shim, Y. K. Lee

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Ceramic ferrites can be used to cancer-treatment. Heating of certain organs or tissue up to temperature between 42°C and 45°C preferentially for cancer therapy is called hyperthermia. We synthesized ferrites with various compositions in the system Co1-xNixFe2O 4 as hyperthermic thermoseed in cancer-treatment and evaluated their effects on the necrosis of cancer cells under alternating magnetic field in vivo as well as in vitro. When a CoFe2O4 was placed into 0.2 ml distilled water, the greatest temperature change in this study, Δ T=29.3°C, was observed. More than half of the carcinoma cells were dead after exposure to alternating magnetic field using CoFe2O 4, while normal cells were survived more than 60%. The injection of this ferrite particles into the tumor bearing mice was able to suppress the number and volume of tumors. CoFe2O4 is expected the useful hyperthermic thermoseed in cancer-treatment because it exhibited the greatest necrosis of carcinoma cells in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)827-830
Number of pages4
JournalKey Engineering Materials
Volume284-286
DOIs
StatePublished - Dec 1 2005

Keywords

  • Alternating magnetic field
  • Cancer-treatment
  • Ferrite
  • Hyperthermia
  • Tumor therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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