In vitro dynamic strain analysis on porcine mitral valve

Z. M. He*, L. Baijens, S. Wanant, P. Shah, S. He, B. Sugimoto, M. S. Sacks, A. P. Yoganathan

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Dual camera stereo photogrammetry was used to quantify the deformation of the central region of the anterior leaflet of the mitral valve operating in a flow loop under the physiological and pathological condition. Stretches and strains were measured and analyzed. The principal stretches demonstrated a rapid rise early in leaflet closure, followed by a plateau, suggesting that the collagen fibers "locked" in place. There is a big difference between the major principal stretch and minor principal stretch. Similar to in-vitro tissue mechanics studies, the transmitral pressure-areal strain relationship during loading and unloading clearly demonstrated hysteresis. Further, this relationship demonstrated a dramatic stiffening attributed to collagen fiber locking. When the data of 3 papillary muscle positions were compared, the leaflet in the slack papillary position showed the highest areal strain rate. The valve exhibited a strongly anisotropic behavior. Papillary muscle position had a small effect on strain measured in the region.

Original languageEnglish (US)
Pages (from-to)1244-1245
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Collagen orientation distribution
  • Marker technique
  • Porcine mitral valve
  • Strain measurement

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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