Sodium acetrizoate 24% was found in vitro to be bacteriocidal to live strains each of Escherichia coli, Proteus, Klebsiella, and Pseudomonas which were isolated from children with urinary tract infections; 25% sodium diatrizoate was bacteriostatic to these same strains in vitro, except for the E. coli strains, for which it was bacteriocidal. The theoretical implications of these findings, if applicable to clinical situations, are that sodium acetrizoate would be the contrast medium of choice for cystourethrography in a patient with retained urine after the procedure (e.g., in neurogenic bladder), while sodium diatrizoate would be the agent of choice if the possibility for soft tissue extravasation exists.
- Iodine-containing compounds
- Urinary infection
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging