In vitro effect of phencyclidine and other psychomotor stimulants in serotonin uptake in human platelets

R. C. Arora; H. Y. Meltzer

doi:10.1016/0024-3205(80)90571-8

In vitro effect of phencyclidine and other psychomotor stimulants in serotonin uptake in human platelets

R. C. Arora, H. Y. Meltzer

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake. Phencyclidine (IC₅₀, 2.5 μM) was one-hundredth as potent as fluoxetine (IC₅₀, 22 νM) but ten times more potent than ketamine (IC₅₀, 25 μM) and d-amphetamine (IC₅₀, 24 μM) and three times more potent than 1-amphetamine (IC₅₀, 80 μM) in inhibition of 5-HT uptake by human blood platelets. The possibility that inhibition of 5-HT may contribute to some of the proposed serotonergic effects of psychomotor stimulants is discussed.

Original language	English (US)
Pages (from-to)	1607-1613
Number of pages	7
Journal	Life Sciences
Volume	27
Issue number	17
DOIs	https://doi.org/10.1016/0024-3205(80)90571-8
State	Published - 1980

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake. Phencyclidine (IC50, 2.5 μM) was one-hundredth as potent as fluoxetine (IC50, 22 νM) but ten times more potent than ketamine (IC50, 25 μM) and d-amphetamine (IC50, 24 μM) and three times more potent than 1-amphetamine (IC50, 80 μM) in inhibition of 5-HT uptake by human blood platelets. The possibility that inhibition of 5-HT may contribute to some of the proposed serotonergic effects of psychomotor stimulants is discussed.",

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AU - Arora, R. C.

AU - Meltzer, H. Y.

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N2 - Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake. Phencyclidine (IC50, 2.5 μM) was one-hundredth as potent as fluoxetine (IC50, 22 νM) but ten times more potent than ketamine (IC50, 25 μM) and d-amphetamine (IC50, 24 μM) and three times more potent than 1-amphetamine (IC50, 80 μM) in inhibition of 5-HT uptake by human blood platelets. The possibility that inhibition of 5-HT may contribute to some of the proposed serotonergic effects of psychomotor stimulants is discussed.

AB - Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake. Phencyclidine (IC50, 2.5 μM) was one-hundredth as potent as fluoxetine (IC50, 22 νM) but ten times more potent than ketamine (IC50, 25 μM) and d-amphetamine (IC50, 24 μM) and three times more potent than 1-amphetamine (IC50, 80 μM) in inhibition of 5-HT uptake by human blood platelets. The possibility that inhibition of 5-HT may contribute to some of the proposed serotonergic effects of psychomotor stimulants is discussed.

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In vitro effect of phencyclidine and other psychomotor stimulants in serotonin uptake in human platelets

Abstract

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