In vitro effect of phencyclidine and other psychomotor stimulants in serotonin uptake in human platelets

R. C. Arora, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake. Phencyclidine (IC50, 2.5 μM) was one-hundredth as potent as fluoxetine (IC50, 22 νM) but ten times more potent than ketamine (IC50, 25 μM) and d-amphetamine (IC50, 24 μM) and three times more potent than 1-amphetamine (IC50, 80 μM) in inhibition of 5-HT uptake by human blood platelets. The possibility that inhibition of 5-HT may contribute to some of the proposed serotonergic effects of psychomotor stimulants is discussed.

Original languageEnglish (US)
Pages (from-to)1607-1613
Number of pages7
JournalLife Sciences
Volume27
Issue number17
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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