@article{9e6b9401e1834c34847562398ccfda5d,
title = "In vitro follicle growth supports human oocyte meiotic maturation",
abstract = "In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles developed from the preantral to antral stage, and, for the first time, produced meiotically competent metaphase II (MII) oocytes after in vitro maturation (IVM).",
author = "Shuo Xiao and Jiyang Zhang and Romero, {Megan M.} and Smith, {Kristin N.} and Shea, {Lonnie D.} and Woodruff, {Teresa K.}",
note = "Funding Information: We thank all patients who donated their ovarian tissues for fertility preservation research through the Oncofertility Consortium, Keisha M. Barreto (Northwestern University Ovarian Histology: P01HD021921) for sectioning our follicle samples, Brigid Martz Smith for management of the National Physicians Cooperative, and Stacey C. Tobin for editorial assistance on the manuscript. This work was supported by P50HD076188 to T.K. Woodruff from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).",
year = "2015",
month = nov,
day = "27",
doi = "10.1038/srep17323",
language = "English (US)",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}