In vitro follicle growth supports human oocyte meiotic maturation

Shuo Xiao, Jiyang Zhang, Megan M. Romero, Kristin N. Smith, Lonnie D. Shea, Teresa K. Woodruff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles developed from the preantral to antral stage, and, for the first time, produced meiotically competent metaphase II (MII) oocytes after in vitro maturation (IVM).

Original languageEnglish (US)
Article number17323
JournalScientific reports
StatePublished - Nov 27 2015

ASJC Scopus subject areas

  • General

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