In vitro identification of angioplasty-induced injury by use of vascular acoustic emissions

Michael J. Vonesh, Lyle F. Mockros, Charles J Davidson, Krishnan B. Chandran, David D. McPherson*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: We have developed a novel method of diagnosing stress- induced vascular injury. This approach uses the sound energy released from atherosclerotic arterial tissue during in vitro balloon angioplasty to characterize type and severity of induced trauma. Methods and Results: Thirty-two postmortem human peripheral arterial specimens 1.0 cm long were subjected to in vitro balloon angioplasty with simultaneous acoustic emission monitoring. Specimens were examined before and after angioplasty to ascertain the extent of angioplasty-induced injury. Gross observation was used to identify dissection. A three-dimensional intravascular ultrasound reconstruction technique was used to estimate the luminal surface area of the specimen. Change in luminal surface area (postangioplasty minus preangioplasty) was used to quantify induced injury. The energy content and spectral distribution of the digitally acquired vascular acoustic emission (VAE) signals were computed. Comparisons of angioplasty-induced trauma with VAE signal characteristics were made. Dissection (mural laceration of variable depth) was observed in 15 of 32 specimens. Eleven showed no evidence of induced dissection, and 6 had preexisting intimal disruptions. The energy content of the VAE signals collected from specimens with dissection was greater than that obtained from those in which dissection was absent: 845±89.4 mJ (mean±SEM; n=15) versus 128±40.8 mJ (n=11; P<.001). Comparison of induced trauma and VAE signal energy demonstrated a proportional relationship (r=.87, P<.001, n=32). Conclusions: VAE signals contain information characterizing type and severity of angioplasty-induced arterial injury. Because vascular injury is related to adverse procedural outcome, development of VAE technology as an adjunct to conventional diagnostic modalities may facilitate optimal balloon angioplasty delivery and postprocedural care.

Original languageEnglish (US)
Pages (from-to)1022-1029
Number of pages8
JournalCirculation
Volume95
Issue number4
DOIs
StatePublished - Jan 1 1997

Keywords

  • angioplasty
  • atherosclerosis
  • balloon
  • coronary disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'In vitro identification of angioplasty-induced injury by use of vascular acoustic emissions'. Together they form a unique fingerprint.

  • Cite this