In vitro ligand binding of125I-recombinant human activin a to the female rat brain

Lyn Jakeman, Jennie Mather, Teresa Woodruff*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Activin has been localized within cells and terminals in the brain. However, little is known about the site of action of this hormone within the brain. In the present study in vitro ligand autoradiography was used to determine the distribution of high affinity binding sites for125 I-rh activin A in rat brain. The highest density of binding sites were concentrated in the amygdala and other forebrain limbic structures. Binding was saturable in selected amygdala nuclei with an apparent Kd of -0.2 nM.125Irh activin A binds specifically in regions known to contain terminals immunoreactive for this hormone, and also at sites distinct from the location of activin A containing neuronal terminals (e g. the ventral limbic system).

Original languageEnglish (US)
Pages (from-to)3117-3119
Number of pages3
JournalEndocrinology
Volume131
Issue number6
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Endocrinology

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