In vitro release kinetics study of diclofenac sodium from acrylic polymer coated pellets

Golam Kibria, Reza-ul-Jalil

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The aim of the present study is to investigate the effect of Ammonio Methacrylate Copolymer Type B (Eudragit RS 30 D) on the release kinetics study of diclofenac sodium form coated pellets. The effect of the incorporation of xanthan gum into the coating formulation was also the goal of this study. Eudragit RS 30 D and xanthan gum was added into the formulation at 5:1 ratio. Different percent of this polymeric combination was loaded on to the drug-loaded pellets. It was found that the cumulative % release of drug decreased with the increase of polymer load in all cases. From all formulations it was observed that the release of diclofenac sodium in 0.1N HCl media was very low (maximum 3.5%) at first 2 hours. Better sustaining effect was found from Eudragit RS 30 D and xanthan gum combinations. Drug was released linearly along with time throughout the whole dissolution process in phosphate buffer (pH 6.8) and it was also revealed that, in all cases the release of diclofenac sodium followed mixed release kinetics but zero order release kinetics predominates.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalDhaka University Journal of Pharmaceutical Sciences
Volume6
Issue number1
DOIs
StatePublished - Jun 2007

Keywords

  • Diclofenac sodium
  • In vitro
  • Kinetic analysis
  • Pellets
  • Sustained release

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology (medical)

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