In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

James A. Winkelmann; Aya Eid; The Quyen Nguyen; B. U.I. Thang; Y. I. Ji; Vadim Backman

doi:10.1364/OL.43.000619

In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

James A. Winkelmann^*, Aya Eid, The Quyen Nguyen, B. U.I. Thang, Y. I. Ji, Vadim Backman

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe’s large visible bandwidth (500–695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ~1.1 μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.

Original language	English (US)
Pages (from-to)	619-622
Number of pages	4
Journal	Optics Letters
Volume	43
Issue number	3
DOIs	https://doi.org/10.1364/OL.43.000619
State	Published - Feb 1 2018

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OL.43.000619

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abstract = "We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe{\textquoteright}s large visible bandwidth (500–695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ~1.1 μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.",

author = "Winkelmann, {James A.} and Aya Eid and Nguyen, {The Quyen} and Thang, {B. U.I.} and Ji, {Y. I.} and Vadim Backman",

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T1 - In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

AU - Winkelmann, James A.

AU - Eid, Aya

AU - Nguyen, The Quyen

AU - Thang, B. U.I.

AU - Ji, Y. I.

AU - Backman, Vadim

PY - 2018/2/1

Y1 - 2018/2/1

N2 - We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe’s large visible bandwidth (500–695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ~1.1 μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.

AB - We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe’s large visible bandwidth (500–695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ~1.1 μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.

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In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

Abstract

ASJC Scopus subject areas

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