In vivo cross-match by chromium-51 urinary excretion from labeled erythrocytes: A case of anti-Gerbich

T. Mochizuki, W. N. Tauxe*, G. Ramsey

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We studied a patient with an alloantibody to the high-frequency red blood cell (RBC) antigen Gerbich. A nationwide search for rare Gerbich-negative blood (<1:45,000 donors) located only seven units, and our supply was quickly exhausted. By using an in vivo cross-matching method, we demonstrated that this anti-Gerbich did not cause RBC destruction. Regular Gerbich-positive transfusions could then proceed without hemolysis. This cross-match test was based on the determination of the urinary excretion rates of injected radioactive chromium-labeled donor erythrocytes by which it was possible to determine compatibility only 24 hr after the test was begun. The procedure provides an easy and accurate means for in vivo cross-matching of conventionally incompatible donor blood.

Original languageEnglish (US)
Pages (from-to)2042-2045
Number of pages4
JournalJournal of Nuclear Medicine
Volume31
Issue number12
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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