In vivo determinations of labelling index of metastatic colorectal carcinoma and normal colonic mucosa using intravenous infusions of bromodeoxyuridine

S. Khan*, A. Raza, N. Petrelli, A. Mittleman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In vivo determination of the labelling index of metastatic colon carcinoma was performed in 14 patients following intravenous infusion of bromodeoxyuridine (BrdU), at doses of 100 and 50 mg/M2. No toxicity was seen. Labelled cells were detected by an immunohistochemical technique using a monoclonal antibody to BrdU. Labelling was uniform and highly specific with good preservation of morphology. Labelling index values ranged from 15.0–40.6% for metastatic lesions and 3.6%–20% for normal colonic mucosa, with mean values of 24% and 11%, respectively. This represents a useful new method for in vivo labelling index determination in solid tumors.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalJournal of Surgical Oncology
Volume39
Issue number2
DOIs
StatePublished - Jan 1 1988

Keywords

  • cell‐kinetics
  • colon cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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