In vivo effect of prothymosin-alpha 1 on humoral and cell-mediated immune responses in the Young rat

Dragan Maric, Jelena Veljić, Jovan Ranin, Branislav D. Janković*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

There is a large body of evidence for the role of thymosin peptides in immunogenesis and immunity. In this paper we report on the influence of prothymosin alpha 1 (ProT-α a hormone-like peptide derived from the calf thymus, on humoral and cellular immune reactions in the rat. Young adult rats received intraperitoneal injections of ProT-α 1 in the periods before and after immunization with cellular and soluble antigens. ProT-αtreatment produced a dose-dependent increase of both humoral and cell-mediated immune responses. The thymus weight increased but not that of spleen. Treatment of nonimmunized rats with this polypeptide significantly elevated the number of CD4+ and decreased the number of CD8+ cells in the peripheral blood. The results suggest a potent immunostimulatory activity of ProT-α 1 and imply direct action of this polypeptide on T lymphocytes.

Original languageEnglish (US)
Pages (from-to)135-142
Number of pages8
JournalInternational Journal of Neuroscience
Volume59
Issue number1-3
DOIs
StatePublished - Jan 1 1991

Keywords

  • Cell-mediated immune response
  • Humoral immune response
  • Immunomodulation
  • Prothymosin-alpha 1
  • Thymosin

ASJC Scopus subject areas

  • Neuroscience(all)

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