In vivo glucose measurement by surface-enhanced Raman spectroscopy

Douglas A. Stuart; Jonathan M. Yuen; Nilam Shah; Olga Lyandres; Chanda R. Yonzon; Matthew R. Glucksberg; Joseph T. Walsh; Richard P. Van Duyne

doi:10.1021/ac061238u

In vivo glucose measurement by surface-enhanced Raman spectroscopy

Douglas A. Stuart, Jonathan M. Yuen, Nilam Shah, Olga Lyandres, Chanda R. Yonzon, Matthew R. Glucksberg, Joseph T. Walsh, Richard P. Van Duyne^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

297 Scopus citations

Abstract

This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).

Original language	English (US)
Pages (from-to)	7211-7215
Number of pages	5
Journal	Analytical Chemistry
Volume	78
Issue number	20
DOIs	https://doi.org/10.1021/ac061238u
State	Published - Oct 15 2006

ASJC Scopus subject areas

Analytical Chemistry

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title = "In vivo glucose measurement by surface-enhanced Raman spectroscopy",

abstract = "This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).",

author = "Stuart, {Douglas A.} and Yuen, {Jonathan M.} and Nilam Shah and Olga Lyandres and Yonzon, {Chanda R.} and Glucksberg, {Matthew R.} and Walsh, {Joseph T.} and {Van Duyne}, {Richard P.}",

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AU - Stuart, Douglas A.

AU - Yuen, Jonathan M.

AU - Shah, Nilam

AU - Lyandres, Olga

AU - Yonzon, Chanda R.

AU - Glucksberg, Matthew R.

AU - Walsh, Joseph T.

AU - Van Duyne, Richard P.

PY - 2006/10/15

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AB - This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).

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