In vivo glucose measurement by surface-enhanced Raman spectroscopy

Douglas A. Stuart, Jonathan M. Yuen, Nilam Shah, Olga Lyandres, Chanda R. Yonzon, Matthew R. Glucksberg, Joseph T. Walsh, Richard P. Van Duyne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

297 Scopus citations


This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).

Original languageEnglish (US)
Pages (from-to)7211-7215
Number of pages5
JournalAnalytical Chemistry
Issue number20
StatePublished - Oct 15 2006

ASJC Scopus subject areas

  • Analytical Chemistry

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