In vivo integrated photoacoustic ophthalmoscopy, optical coherence tomography, and scanning laser ophthalmoscopy for retinal imaging

Wei Song*, Rui Zhang, Hao F. Zhang, Qing Wei, Wenwu Cao

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The physiological and pathological properties of retina are closely associated with various optical contrasts. Hence, integrating different ophthalmic imaging technologies is more beneficial in both fundamental investigation and clinical diagnosis of several blinding diseases. Recently, photoacoustic ophthalmoscopy (PAOM) was developed for in vivo retinal imaging in small animals, which demonstrated the capability of imaging retinal vascular networks and retinal pigment epithelium (RPE) at high sensitivity. We combined PAOM with traditional imaging modalities, such as fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), and auto-fluorescence scanning laser ophthalmoscopy (AF-SLO), for imaging rats and mice. The multimodal imaging system provided more comprehensive evaluation of the retina based on the complementary imaging contrast mechanisms. The high-quality retinal images show that the integrated ophthalmic imaging system has great potential in the investigation of blinding disorders.

Original languageEnglish (US)
Title of host publicationOptics in Health Care and Biomedical Optics V
DOIs
StatePublished - Dec 1 2012
EventOptics in Health Care and Biomedical Optics V - Beijing, China
Duration: Nov 5 2012Nov 7 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8553
ISSN (Print)1605-7422

Other

OtherOptics in Health Care and Biomedical Optics V
CountryChina
CityBeijing
Period11/5/1211/7/12

Keywords

  • Photoacoustic ophthalmoscopy
  • auto-fluorescence laser scanning ophthalmoscopy
  • in vivo retinal imaging
  • optical coherence tomography, fluorescein angiography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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