In vivo measurement of the shape of the tissuerefractive-index correlation function and its application to detection of colorectal field carcinogenesis

Andrew J. Gomes, Sarah Ruderman, Mart DelaCruz, Ramesh K. Wali, Hemant K. Roy, Vadim Backman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Polarization-gated spectroscopy is an established method to depth-selectively interrogate the structural properties of biological tissue. We employ this method in vivo in the azoxymethane (AOM)-treated rat model to monitor the morphological changes that occur in the field of a tumor during early carcinogenesis. The results demonstrate a statistically significant change in the shape of the refractive-index correlation function for AOMtreated rats versus saline-treated controls. Since refractive index is linearly proportional to mass density, these refractive-index changes can be directly linked to alterations in the spatial distribution patterns of macromolecular density. Furthermore, we found that alterations in the shape of the refractive-index correlation function shape were an indicator of both present and future risk of tumor development. These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development.

Original languageEnglish (US)
Article number047005-1
JournalJournal of Biomedical Optics
Volume17
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Biomedical optics
  • Endoscopy
  • Fiber optics
  • Polarization
  • Refractive index
  • Scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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