In vivo modeling of biofilm-infected wounds: A review

Akhil K. Seth, Matthew R. Geringer, Seok Jong Hong, Kai P. Leung, Thomas A. Mustoe, Robert D Galiano*

*Corresponding author for this work

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Chronic wounds continue to represent a difficult and complex problem for both patients and healthcare providers. Bacterial biofilms represent a critical component of nonhealing wounds, utilizing several different mechanisms to inhibit innate inflammatory pathways and resist traditional therapeutics. Although in vitro biofilm systems have been well described and studied, understanding the intricacies of wound biofilm pathology requires appropriate in vivo models to understand the interactions between bacteria and host. In an effort to clarify the available literature, this review describes and critically evaluates all of the in vivo wound biofilm models currently published to-date, including model advantages and clinical applicability. We will also address the need for continued therapeutic development and testing using these currently available in vivo models.

Original languageEnglish (US)
Pages (from-to)330-338
Number of pages9
JournalJournal of Surgical Research
Volume178
Issue number1
DOIs
StatePublished - Nov 1 2012

Keywords

  • Animal model
  • Bacteria
  • Biofilm
  • Chronic wound
  • In vivo

ASJC Scopus subject areas

  • Surgery

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