In vivo sarcomere imaging and fiber tension measurements

Yi Ning Wu; Yupeng Ren; Li Qun Zhang

doi:10.1109/IEMBS.2010.5627513

In vivo sarcomere imaging and fiber tension measurements

Yi Ning Wu^*, Yupeng Ren, Li Qun Zhang

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Current work demonstrates a new method and a new device for simultaneous in vivo measurements of sarcomere imaging and fiber tension. Sarcomere, a building block of muscles, plays a critical role in muscle contracti on. In the pathological conditions, the biomechanical properties ofsarcomere and muscle fibers may be altered significantly. We developed a novel methodology by combining the optical image capture system with force measurement which allowed us to investigate the muscle cell properties in vivo under monitored/controlled tension. The methodology was validated in an in vivo rat model as well as using an in vitro corroboration setup. The in vivo evaluation provides us a powerful tool to investigate pathological changes of fibers/sarcomeres and help determine proper treatment.

Original language	English (US)
Title of host publication	2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages	1986-1989
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2010.5627513
State	Published - Dec 1 2010
Event	2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina Duration: Aug 31 2010 → Sep 4 2010

Publication series

Name	2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Other

Other	2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Country/Territory	Argentina
City	Buenos Aires
Period	8/31/10 → 9/4/10

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Signal Processing
Biomedical Engineering
Health Informatics

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10.1109/IEMBS.2010.5627513

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Wu, Y. N., Ren, Y., & Zhang, L. Q. (2010). In vivo sarcomere imaging and fiber tension measurements. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (pp. 1986-1989). Article 5627513 (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10). https://doi.org/10.1109/IEMBS.2010.5627513

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title = "In vivo sarcomere imaging and fiber tension measurements",

abstract = "Current work demonstrates a new method and a new device for simultaneous in vivo measurements of sarcomere imaging and fiber tension. Sarcomere, a building block of muscles, plays a critical role in muscle contracti on. In the pathological conditions, the biomechanical properties ofsarcomere and muscle fibers may be altered significantly. We developed a novel methodology by combining the optical image capture system with force measurement which allowed us to investigate the muscle cell properties in vivo under monitored/controlled tension. The methodology was validated in an in vivo rat model as well as using an in vitro corroboration setup. The in vivo evaluation provides us a powerful tool to investigate pathological changes of fibers/sarcomeres and help determine proper treatment.",

author = "Wu, {Yi Ning} and Yupeng Ren and Zhang, {Li Qun}",

year = "2010",

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day = "1",

doi = "10.1109/IEMBS.2010.5627513",

language = "English (US)",

isbn = "9781424441235",

series = "2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10",

pages = "1986--1989",

booktitle = "2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10",

note = "2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 ; Conference date: 31-08-2010 Through 04-09-2010",

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Wu, YN, Ren, Y & Zhang, LQ 2010, In vivo sarcomere imaging and fiber tension measurements. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10., 5627513, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, pp. 1986-1989, 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina, 8/31/10. https://doi.org/10.1109/IEMBS.2010.5627513

In vivo sarcomere imaging and fiber tension measurements. / Wu, Yi Ning; Ren, Yupeng; Zhang, Li Qun.
2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1986-1989 5627513 (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Current work demonstrates a new method and a new device for simultaneous in vivo measurements of sarcomere imaging and fiber tension. Sarcomere, a building block of muscles, plays a critical role in muscle contracti on. In the pathological conditions, the biomechanical properties ofsarcomere and muscle fibers may be altered significantly. We developed a novel methodology by combining the optical image capture system with force measurement which allowed us to investigate the muscle cell properties in vivo under monitored/controlled tension. The methodology was validated in an in vivo rat model as well as using an in vitro corroboration setup. The in vivo evaluation provides us a powerful tool to investigate pathological changes of fibers/sarcomeres and help determine proper treatment.

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In vivo sarcomere imaging and fiber tension measurements

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