Inability of Simian Virus 40 to Establish Productive Infection of Lymphoblastic Cell Lines

Sophie Shaikh, Christine Skoczylas, Richard Longnecker, Kathleen Rundell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Lymphoblastic cell lines were infected with simian virus 40 (SV40) and then monitored for evidence of a productive infection. No evidence of early gene expression was found 2 days following infection, as determined by assaying viral mRNAs and early antigens. Furthermore, only small amounts of virus could be detected by plaque assay 2 days after infection, and levels slowly declined until they were undetectable after a few weeks in culture. Thus, human lymphocytes are not readily infectible with SV40 and do not provide a simple model for studying interactions of SV40 with a human cell type.

Original languageEnglish (US)
Pages (from-to)4917-4920
Number of pages4
JournalJournal of virology
Volume78
Issue number9
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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