Inactivation of γ-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism

Mengmeng Fu, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Inactivation of pyridoxal 5′-phosphate (PLP)-dependent γ-aminobutryic acid aminotransferase by (S)-4-amino-4,5-dihydro-2- furancarboxylic acid (SADFA) gives pyridoxamine 5′-phosphate, not the expected SADFA-PLP aromatization product. Inactivation appears to proceed by a Michael addition/hydrolysis mechanism instead.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number1
DOIs
StatePublished - Jan 5 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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