Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue

Andrew J. Leon; Richard B. Silverman

doi:10.1016/0960-894X(96)00226-0

Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue

Andrew J. Leon, Richard B. Silverman^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

(Z)-4-Amino-6-fluoro-5-hexenoic acid is a mechanism-based inactivator of pig brain γ-aminobutyric acid (GABA) aminotransferase. An active site residue to which this inactivator attaches is Cys-294. This is the first time a residue other than the lysine to which PLP is bound has been implicated in active site labeling.

Original language	English (US)
Pages (from-to)	1319-1322
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/0960-894X(96)00226-0
State	Published - Jun 18 1996

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(96)00226-0

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title = "Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue",

abstract = "(Z)-4-Amino-6-fluoro-5-hexenoic acid is a mechanism-based inactivator of pig brain γ-aminobutyric acid (GABA) aminotransferase. An active site residue to which this inactivator attaches is Cys-294. This is the first time a residue other than the lysine to which PLP is bound has been implicated in active site labeling.",

author = "Leon, {Andrew J.} and Silverman, {Richard B.}",

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T1 - Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid

T2 - Identification of an active site residue

AU - Leon, Andrew J.

AU - Silverman, Richard B.

PY - 1996/6/18

Y1 - 1996/6/18

N2 - (Z)-4-Amino-6-fluoro-5-hexenoic acid is a mechanism-based inactivator of pig brain γ-aminobutyric acid (GABA) aminotransferase. An active site residue to which this inactivator attaches is Cys-294. This is the first time a residue other than the lysine to which PLP is bound has been implicated in active site labeling.

AB - (Z)-4-Amino-6-fluoro-5-hexenoic acid is a mechanism-based inactivator of pig brain γ-aminobutyric acid (GABA) aminotransferase. An active site residue to which this inactivator attaches is Cys-294. This is the first time a residue other than the lysine to which PLP is bound has been implicated in active site labeling.

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IS - 12

ER -

Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue

Abstract

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