Inactivation of γ-aminobutyric acid aminotransferase by (Z)-4-amino-6-fluoro-5-hexenoic acid: Identification of an active site residue

Andrew J. Leon, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

(Z)-4-Amino-6-fluoro-5-hexenoic acid is a mechanism-based inactivator of pig brain γ-aminobutyric acid (GABA) aminotransferase. An active site residue to which this inactivator attaches is Cys-294. This is the first time a residue other than the lysine to which PLP is bound has been implicated in active site labeling.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number12
DOIs
StatePublished - Jun 18 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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