Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct

Deanna J. Mitchell, Dejan Nikolic, Richard B. Van Breemen, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Incubation of 1-phenylcyclopropylamine with bovine liver MAO (MAO B), followed by complete enzymatic digestion to single amino acid residues and subsequent analysis by on-line liquid chromatography-electrospray ionization mass spectrometry, was used to investigate the resulting flavin adduct structure.

Original languageEnglish (US)
Pages (from-to)1757-1760
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number13
DOIs
StatePublished - Jul 9 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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