Inactivity produces increases in neurotransmitter release and synapse size

Venkatesh N. Murthy, Thomas Schikorski, Charles F. Stevens*, Yongling Zhu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

477 Scopus citations


When hippocampal synapses in culture are pharmacologically silenced for several days, synaptic strength increases. The structural correlate of this change in strength is an increase in the size of the synapses, with all synaptic components - active zone, postsynaptic density, and bouton - becoming larger. Further, the number of docked vesicles and the total number of vesicles per synapse increases, although the number of docked vesicles per area of active zone is unchanged. In parallel with these anatomical changes, the physiologically measured size of the readily releasable pool (RRP) and the release probability are increased. Ultrastructural analysis of individual synapses in which the RRP was previously measured reveals that, within measurement error, the same number of vesicles are docked as are estimated to be in the RRP.

Original languageEnglish (US)
Pages (from-to)673-682
Number of pages10
Issue number4
StatePublished - Nov 20 2001

ASJC Scopus subject areas

  • Neuroscience(all)


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