Abstract
The objective of this single-center cohort study was to characterize the frequency, clinical characteristics, and molecular epidemiology of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after vaccination. Between May 15, 2021, and January 1, 2022, 171 children experienced SARS-CoV-2 infection postvaccination, 146 (86%) following the Omicron variant predominance. Outcomes were generally mild and comparable before and after Omicron predominance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 196-201.e4 |
| Journal | journal of pediatrics |
| Volume | 251 |
| DOIs | |
| State | Published - Dec 2022 |
Funding
We thank the staff at the Clinical Microbiology and Special Infectious Diseases laboratories at Lurie Children's Hospital for their assistance in saving and processing specimens for WGS and the Regional Innovative Public Health Laboratory at the Chicago Department of Public Health and Rush University Medical Center for their sequencing of some samples included in this study. WGS data collection was supported in part through the computational resources and staff contributions provided for the Quest high-performance computing facility at Northwestern University, which is jointly supported by the Office of the Provost, Office for Research, and Northwestern University Information Technology. This work was supported by funding from the Walder Foundation's Chicago Coronavirus Assessment Network (Chicago CAN) Initiative. Additional funding for whole-genome sequencing and variant identification was provided by National Institutes of Health Grants R21 AI163912 (to J.H.) and U19 AI135964 (to E.O.). The authors declare no conflicts of interest.
Keywords
- COVID-19
- SARS-CoV-2
- breakthrough
- pediatric
- vaccine
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
