Incidence and impact of false-positive urine pneumococcal antigen testing in hospitalized patients

Patrick A. Ryscavage*, Gary A. Noskin, Anne Bobb, Laura Bardowski, Teresa R. Zembower

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

OBJECTIVES: Immunochromatographic urine pneumococcal antigen testing (ICT) has become a common diagnostic tool for those presenting with possible invasive pneumococcal disease. The incidence and clinical impact of ICT false-positivity on hospitalized patients has not been assessed outside of specific patient subpopulations. ICT performance needs to be assessed in a real-world clinical setting. This study aims to describe the incidence and clinical impact of ICT false-positivity in a hospital setting over a 19-month period. METHODS: A retrospective cohort study was performed to assess the incidence of false-positive (FP) ICT among hospitalized patients from November 21, 2007 to June 30, 2009. The primary objective was to describe the incidence of FP ICT results. The secondary objective was to describe what clinical impact, if any, could be attributed to FP ICT results. RESULTS: During the study period, 52 positive ICT results were obtained, of which 5 (9.6%) were deemed falsely positive. Interestingly, two of the 5 FP results were from patients who had received 23-valent pneumococcal vaccine (PPV) in the 2 days prior to ICT. The management of all 5 patients was impacted by the FP results through unnecessary antimicrobial treatment and/or deferral of further clinical evaluation. CONCLUSION: Health care providers should be aware of the potential for ICT FP and should order and interpret these tests within an informed clinical framework.

Original languageEnglish (US)
Pages (from-to)593-597
Number of pages5
JournalSouthern Medical Journal
Volume104
Issue number8
DOIs
StatePublished - Aug 1 2011

Keywords

  • Streptococcus pneumoniae
  • immunochromatographic urine pneumococcal antigen test
  • pneumococcal polysaccharide vaccine

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Incidence and impact of false-positive urine pneumococcal antigen testing in hospitalized patients'. Together they form a unique fingerprint.

Cite this