Abstract
Objectives: To determine the incidence of cardiopulmonary resuscitation in PICUs and subsequent outcomes. Design, Setting, and Patients: Multicenter prospective observational study of children younger than 18 years old randomly selected and intensively followed from PICU admission to hospital discharge in the Collaborative Pediatric Critical Care Research Network December 2011 to April 2013. Results: Among 10,078 children enrolled, 139 (1.4%) received cardiopulmonary resuscitation for more than or equal to 1 minute and/or defibrillation. Of these children, 78% attained return of circulation, 45% survived to hospital discharge, and 89% of survivors had favorable neurologic outcomes. The relative incidence of cardiopulmonary resuscitation events was higher for cardiac patients compared with non-cardiac patients (3.4% vs 0.8%, p <0.001), but survival rate to hospital discharge with favorable neurologic outcome was not statistically different (41% vs 39%, respectively). Shorter duration of cardiopulmonary resuscitation was associated with higher survival rates: 66% (29/44) survived to hospital discharge after 1-3 minutes of cardiopulmonary resuscitation versus 28% (9/32) after more than 30 minutes (p < 0.001). Among survivors, 90% (26/29) had a favorable neurologic outcome after 1-3 minutes versus 89% (8/9) after more than 30 minutes of cardiopulmonary resuscitation. Conclusions: These data establish that contemporary PICU cardiopulmonary resuscitation, including long durations of cardiopulmonary resuscitation, results in high rates of survival-to-hospital discharge (45%) and favorable neurologic outcomes among survivors (89%). Rates of survival with favorable neurologic outcomes were similar among cardiac and noncardiac patients. The rigorous prospective, observational study design avoided the limitations of missing data and potential selection biases inherent in registry and administrative data.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 798-808 |
| Number of pages | 11 |
| Journal | Critical care medicine |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2016 |
Funding
We acknowledge the important contributions of the following research coordinators and data coordinating center staff: Teresa Liu, MPH, CCRP, and Jeri Burr, MS, RN-BC, CCRN, from the University of Utah; Mary Ann DiLiberto, BS, RN, CCRC, and Carol Ann Twelves, BS, RN, from the Children’s Hospital of Philadelphia; Jean Reardon, MA, BSN, RN, from Children’s National Medical Center; Aimee Labell, MS, RN, from Phoenix Children’s Hospital; Jeffrey Terry, MBA, from Children’s Hospital Los Angeles; Rica Morzov, RN, BSN, from Children’s Hospital Los Angeles; Margaret Villa, RN, from Children’s Hospital Los Angeles and Mattel Children’s Hospital; Mary Ann Nyc, BS, from UCLA Mattel Children’s Hospital; Jeni Kwok, JD, from Children’s Hospital of Los Angeles; Ann Pawluszka, BSN, RN, from Children’s Hospital of Michigan; Monica S. Weber, RN, BSN, CCRP, from University of Michigan; and Alan C. Abraham, BA, CCRC, from University of Pittsburgh Medical Center.
Keywords
- cardiac arrest
- cardiopulmonary resuscitation
- children
- incidence
- intensive care
- survival
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine