Abstract
OBJECTIVE To use the national Surveillance, Epidemiology, and End Results (SEER) cancer registry to describe the natural history, national incidence and treatment patterns for ductal prostate cancer (PCa) over the last 20 years, as the available literature on ductal PCa is limited to small case series because of few patient numbers. PATIENTS AND METHODS From the SEER registry, 693 men with ductal PCa were identified from 1970. The demographics, clinical features and cause of death data were collected from men with ductal and acinar histological types. RESULTS The incidence of ductal PCa has increased over each decade, but the overall percentage of ductal relative to acinar PCa has remained stable. Men with ductal PCa were more likely to present with advanced disease (30% T3 with ductal PCa, compared with 7% with acinar PCa). Men with ductal PCa underwent similar rates of radical surgery, lower rates of radiotherapy but a higher frequency of outlet (transurethral resection) procedures. Men with ductal PCa had a significantly greater rate of death from PCa (12% vs 4%) than men with acinar PCa. Comparing PCa-specific mortality, men with ductal PCa had similar rates of death to men with Gleason 4 + 4 grade acinar PCa. CONCLUSIONS Despite a stable incidence, ductal PCa remains an aggressive PCa usually presenting with advanced clinical stage and resulting in a high rate of PCa-specific mortality similar to Gleason 4 + 4 acinar PCa. Patients would probably benefit from combined modalities including radical surgery, radiotherapy and palliative outlet procedures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 831-834 |
| Number of pages | 4 |
| Journal | BJU International |
| Volume | 109 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 1 2012 |
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Keywords
- incidence
- pathology
- prostate cancer
ASJC Scopus subject areas
- Urology
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Incidence and outcomes of ductal carcinoma of the prostate in the USA : Analysis of data from the Surveillance, Epidemiology, and End Results program. / Meeks, Joshua J; Zhao, Lee C.; Cashy, John; Kundu, Shilajit D.
In: BJU International, Vol. 109, No. 6, 01.03.2012, p. 831-834.Research output: Contribution to journal › Article
TY - JOUR
T1 - Incidence and outcomes of ductal carcinoma of the prostate in the USA
T2 - Analysis of data from the Surveillance, Epidemiology, and End Results program
AU - Meeks, Joshua J
AU - Zhao, Lee C.
AU - Cashy, John
AU - Kundu, Shilajit D
PY - 2012/3/1
Y1 - 2012/3/1
N2 - OBJECTIVE To use the national Surveillance, Epidemiology, and End Results (SEER) cancer registry to describe the natural history, national incidence and treatment patterns for ductal prostate cancer (PCa) over the last 20 years, as the available literature on ductal PCa is limited to small case series because of few patient numbers. PATIENTS AND METHODS From the SEER registry, 693 men with ductal PCa were identified from 1970. The demographics, clinical features and cause of death data were collected from men with ductal and acinar histological types. RESULTS The incidence of ductal PCa has increased over each decade, but the overall percentage of ductal relative to acinar PCa has remained stable. Men with ductal PCa were more likely to present with advanced disease (30% T3 with ductal PCa, compared with 7% with acinar PCa). Men with ductal PCa underwent similar rates of radical surgery, lower rates of radiotherapy but a higher frequency of outlet (transurethral resection) procedures. Men with ductal PCa had a significantly greater rate of death from PCa (12% vs 4%) than men with acinar PCa. Comparing PCa-specific mortality, men with ductal PCa had similar rates of death to men with Gleason 4 + 4 grade acinar PCa. CONCLUSIONS Despite a stable incidence, ductal PCa remains an aggressive PCa usually presenting with advanced clinical stage and resulting in a high rate of PCa-specific mortality similar to Gleason 4 + 4 acinar PCa. Patients would probably benefit from combined modalities including radical surgery, radiotherapy and palliative outlet procedures.
AB - OBJECTIVE To use the national Surveillance, Epidemiology, and End Results (SEER) cancer registry to describe the natural history, national incidence and treatment patterns for ductal prostate cancer (PCa) over the last 20 years, as the available literature on ductal PCa is limited to small case series because of few patient numbers. PATIENTS AND METHODS From the SEER registry, 693 men with ductal PCa were identified from 1970. The demographics, clinical features and cause of death data were collected from men with ductal and acinar histological types. RESULTS The incidence of ductal PCa has increased over each decade, but the overall percentage of ductal relative to acinar PCa has remained stable. Men with ductal PCa were more likely to present with advanced disease (30% T3 with ductal PCa, compared with 7% with acinar PCa). Men with ductal PCa underwent similar rates of radical surgery, lower rates of radiotherapy but a higher frequency of outlet (transurethral resection) procedures. Men with ductal PCa had a significantly greater rate of death from PCa (12% vs 4%) than men with acinar PCa. Comparing PCa-specific mortality, men with ductal PCa had similar rates of death to men with Gleason 4 + 4 grade acinar PCa. CONCLUSIONS Despite a stable incidence, ductal PCa remains an aggressive PCa usually presenting with advanced clinical stage and resulting in a high rate of PCa-specific mortality similar to Gleason 4 + 4 acinar PCa. Patients would probably benefit from combined modalities including radical surgery, radiotherapy and palliative outlet procedures.
KW - incidence
KW - pathology
KW - prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84857656924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857656924&partnerID=8YFLogxK
U2 - 10.1111/j.1464-410X.2011.10520.x
DO - 10.1111/j.1464-410X.2011.10520.x
M3 - Article
C2 - 21883856
AN - SCOPUS:84857656924
VL - 109
SP - 831
EP - 834
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 6
ER -