TY - JOUR
T1 - Incidence of Glaucoma Progression and Rate of Visual Field Deterioration in a Cohort of Urban Ghanaians
AU - Mwanza, Jean Claude
AU - Tulenko, Samantha E.
AU - Budenz, Donald L.
AU - Herndon, Leon W.
AU - Hall, Alyson
AU - Hay-Smith, Graham
AU - Kim, Hanna Y.
AU - Mathenge, Elizabeth
AU - Spratt, Alexander
AU - Tanna, Angelo P.
AU - Barton, Keith
N1 - Publisher Copyright:
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Précis: The annual incidence of glaucoma progression (9.7%) and rates of visual field mean deviation (MD) change in progressors (-1.02±0.06 dB/y) are high in a small cohort of urban Ghanaians. Purpose: To report the incidence of glaucoma progression and the rate of visual field deterioration in a small cohort of Ghanaians. Methods: One hundred ten subjects (204 eyes) diagnosed with glaucoma at a baseline population-based screening examination were re-examined a mean of 8.3±0.8 years later. Eyes were classified as having progressed if the optic disc alone, visual field alone or both showed significant glaucomatous changes on follow-up. Visual field MD was used to calculate the rate of visual field progression. Results: Progression was observed in 89 (80.9%, 9.7%/year) subjects (130 eyes). Progression occurred in 32 (31.7%, 3.8%/year) subjects by optic disc alone (46 eyes), 38 (44.7%, 5.4%/year) subjects by visual field alone (58 eyes), and 19 (25.0%, 3.0%/year) subjects by both modalities (26 eyes). The average rate of change in MD differed significantly between progressors (-1.02±1.06 dB/y) and nonprogressors (+0.089±0.49 dB/y), P=0.001. The rate of visual field worsening was greater among those who were classified as having progressed by both structure and function (-1.29±0.68 dB/y) and by function alone (-1.21±1.20 dB/y) than by structure alone (-0.55±0.76 dB/y). Progression was significantly associated with older age [odds ratio (OR), 1.42; P<0.001] and higher baseline intraocular pressure (OR, 1.18; P=0.002). Factors associated with rate of MD change were baseline older age (OR, 1.66; P=0.003), higher intraocular pressure (OR, 2.81; P=0.007), better visual field MD (OR, 1.41; P=0.004), and systemic hypertension (OR, 1.15; P=0.029). Conclusion: The incidence and rate of visual field progression are high in this longitudinal study of Ghanaian subjects with glaucoma. The findings may have important clinical and public health policy ramifications.
AB - Précis: The annual incidence of glaucoma progression (9.7%) and rates of visual field mean deviation (MD) change in progressors (-1.02±0.06 dB/y) are high in a small cohort of urban Ghanaians. Purpose: To report the incidence of glaucoma progression and the rate of visual field deterioration in a small cohort of Ghanaians. Methods: One hundred ten subjects (204 eyes) diagnosed with glaucoma at a baseline population-based screening examination were re-examined a mean of 8.3±0.8 years later. Eyes were classified as having progressed if the optic disc alone, visual field alone or both showed significant glaucomatous changes on follow-up. Visual field MD was used to calculate the rate of visual field progression. Results: Progression was observed in 89 (80.9%, 9.7%/year) subjects (130 eyes). Progression occurred in 32 (31.7%, 3.8%/year) subjects by optic disc alone (46 eyes), 38 (44.7%, 5.4%/year) subjects by visual field alone (58 eyes), and 19 (25.0%, 3.0%/year) subjects by both modalities (26 eyes). The average rate of change in MD differed significantly between progressors (-1.02±1.06 dB/y) and nonprogressors (+0.089±0.49 dB/y), P=0.001. The rate of visual field worsening was greater among those who were classified as having progressed by both structure and function (-1.29±0.68 dB/y) and by function alone (-1.21±1.20 dB/y) than by structure alone (-0.55±0.76 dB/y). Progression was significantly associated with older age [odds ratio (OR), 1.42; P<0.001] and higher baseline intraocular pressure (OR, 1.18; P=0.002). Factors associated with rate of MD change were baseline older age (OR, 1.66; P=0.003), higher intraocular pressure (OR, 2.81; P=0.007), better visual field MD (OR, 1.41; P=0.004), and systemic hypertension (OR, 1.15; P=0.029). Conclusion: The incidence and rate of visual field progression are high in this longitudinal study of Ghanaian subjects with glaucoma. The findings may have important clinical and public health policy ramifications.
KW - glaucoma progression
KW - incidence
KW - optic disc progression
KW - rate of change
KW - visual field progression
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U2 - 10.1097/IJG.0000000000001984
DO - 10.1097/IJG.0000000000001984
M3 - Article
C2 - 35019875
AN - SCOPUS:85124189778
SN - 1057-0829
VL - 31
SP - 503
EP - 510
JO - Journal of Glaucoma
JF - Journal of Glaucoma
IS - 7
ER -
