Incidence of Nonvertebral Fractures in Relation to Time on Treatment and Bone Density in Glucocorticoid-Treated Patients: A Retrospective Approach

Stefan Goemaere*, U. A. Liberman, J. D. Adachi, F. Hawkins, N. Lane, K. G. Saag, T. Schnitzer, J. M. Kaufman, M. P. Malice, W. Carofano, A. Daifotis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The effects of duration of treatment and bone mineral density (BMD) on nonvertebral fracture in 560 glucocorticoid users were examined by using base-line and retrospective data from 2 parallel studies assessing the efficacy and safety of alendronate therapy. Baseline spine and hip BMD were significantly (P < 0.01) lower with increased time spent receiving glucocorticoids. Forty-three patients (7.7%) had experienced at least 1 nonvertebral fracture after starting glucocorticoid treatment. The hazard function for nonvertebral fracture occurrence increased significantly (P < 0.01) with time spent receiving glucocorticoids: fracture incidence per 1,000 person-years on glucocorticoids was 18 (< 5 years), 31 (5-10 years), and 35 (> 10 years). Patients with a history of nonvertebral fractures after starting glucocorticoid treatment had significantly lower lumbar spine (P < 0.01) and hip (< 0.01) BMD value than those without fractures. This retrospective analysis suggests that a BMD measurement of spine and hip may identify risk for nonvertebral fractures in a heterogeneous population of glucocorticoid users.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalJournal of Clinical Rheumatology
Volume9
Issue number3
DOIs
StatePublished - Jun 1 2003

Keywords

  • Bone mineral density
  • Fracture
  • Glucocorticoids

ASJC Scopus subject areas

  • Rheumatology

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