Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen

S. U. Schuele; C. Kellinghaus; S. J. Shook; N. Boulis; F. A. Bethoux; T. Loddenkemper

doi:10.1212/01.WNL.0000154639.35941.21

Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen

S. U. Schuele^*, C. Kellinghaus, S. J. Shook, N. Boulis, F. A. Bethoux, T. Loddenkemper

^*Corresponding author for this work

Neurology

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58 Scopus citations

Abstract

Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.

Original language	English (US)
Pages (from-to)	1086-1087
Number of pages	2
Journal	Neurology
Volume	64
Issue number	6
DOIs	https://doi.org/10.1212/01.WNL.0000154639.35941.21
State	Published - Mar 22 2005

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.",

author = "Schuele, {S. U.} and C. Kellinghaus and Shook, {S. J.} and N. Boulis and Bethoux, {F. A.} and T. Loddenkemper",

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AU - Schuele, S. U.

AU - Kellinghaus, C.

AU - Shook, S. J.

AU - Boulis, N.

AU - Bethoux, F. A.

AU - Loddenkemper, T.

PY - 2005/3/22

Y1 - 2005/3/22

N2 - Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.

AB - Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.

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JO - Neurology

JF - Neurology

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Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen

Abstract

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