Incidence of yag capsulotomy following glaucoma triple procedure with and without adjunctive mitomycin c

A. L. Weatherwax*, D. H. Shin, R. B. Pearlman, D. Lee, C. Kirn, Y. J. Hong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. Since a measurable and pharmacologically significant amount of mitomycin C {MMC) has been found in the anterior segment and the vitreous compartment following adjunctive subconjunctival application of MMC intraopcratively during trabeculectomy with and without cataract surgery, we investigated the incidence of capsular opacification requiring a YAG capsulotomy following phacoemulsification with 5x6 mm all PMMA small incision intraocular lens implantation and primary trabeculectomy (PGTP) with versus without intraoperative adjunctive subconjunctival MMC. Methods. There were 147 eyes of 147 patients with, and 59 eyes of 59 patients without adjunctive intraoperative subconjunctival MMC (0.5 mg/ml for I or 3 to 5 minutes) during the PGTP. Result. The MMC and control groups were similar in demographic characteristics, preoperative and postoperative intraocular pressures, and numbers of glaucoma medications, percentages of patients on preoperative and postoperative chronic miotics, and severity of glaucoma. Throughout the span of 4 years, the probability of capsular opacification requiring a YAG capsulotomy was significantly higher in the 3 to 5 min MMC subgroup than the l min MMC subgroup and the control group (p=0.02). Conclusions. Thus, the MMC level in the aqueous, intraoperaiively and postoperatively, must have been great enough to be cytotoxic to the lens epithelial cells after 3 to 5 min intraoperative MMC application but not after l min MMC application during the PGTP.

Original languageEnglish (US)
Pages (from-to)S11
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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