Incidental prostatic paraganglia in radical prostatectomy specimens: A diagnostic pitfall

Kruti P. Maniar*, Pamela D. Unger, David B. Samadi, Guang Qian Xiao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Paraganglia are an uncommon but previously reported finding in the genitourinary system. Recognition of this entity in the prostate is important in distinguishing it from prostatic adenocarcinoma. In this series, 1230 radical prostectomy specimens were examined for the presence of paraganglia, and a total of 57 cases (4.5%) were found to contain paraganglia. The majority of paraganglia were extraprostatic and could easily mimic extension of prostatic adenocarcinoma into extraprostatic tissue. It is important to recognize paraganglia, particularly when they are extraprostatic and could confer a falsely higher tumor stage to the patient. The paraganglia demonstrated characteristic histology, and immunohistochemistry was supportive when enough tissue was available. No association between patient age and frequency of paraganglia was found.

Original languageEnglish (US)
Pages (from-to)772-774
Number of pages3
JournalInternational Journal of Surgical Pathology
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2011

Keywords

  • neuroendocrine cells
  • paraganglia
  • prostate cancer mimics
  • prostatectomy
  • prostatic adenocarcinoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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