Abstract
Rats injected daily with cholecystokinin initially inhibited food intake in the first 30 min after injection, but after several days showed an increase in food ingested to an amount that approached their preinjection baseline food intakes and that did not differ from that of rats injected with isotonic saline. This effect occurred with the synthetic C-terminal octapeptide of cholecystokinin and to a lesser extent with injections of natural cholecystokinin extract. It occurred with wet mash and to a lesser extent with liquid diets. When injections were spaced at twice per week, there was an inconsistent response to cholecystokinin but no evidence of habituation. This finding of possible habituation and inconsistent responding to repeated injections of cholecystokinin questions its role as a physiological satiety signal.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 65-72 |
| Number of pages | 8 |
| Journal | Physiology and Behavior |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1978 |
Funding
1Supported by U.S.P.H.S. Grant AM 17,171 to CTS and a granftr om the University of Wisconsin Graduate School to SM. We thank Brian Hollander, D. J. Hyde, Timothy Koschmann, Yvonne Pola, and Timothy Weber for their assistance in these experiments. We also thank Richard Keesey for his helpful comments on an earlier version of this manuscript and Lola Lopes for her statistical advice. Requests for reprints should be sent to Susan Mineka, Department of Psychology, University of Wisconsin, Charter and Johnson Streets, Madison, Wisconsin 53706.
Keywords
- Cholecystokinin
- Habituation
- Inconsistency
- Satiety
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience