| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-403 |
| Number of pages | 4 |
| Journal | The Journal of pediatrics |
| Volume | 116 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1990 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Increase in serum concentration of keratan sulfate after treatment of growth hormone deficiency with growth hormone. / Pachman, Lauren M.; Green, Orville C.; Lenz, Mary E. et al.
In: The Journal of pediatrics, Vol. 116, No. 3, 03.1990, p. 400-403.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Increase in serum concentration of keratan sulfate after treatment of growth hormone deficiency with growth hormone
AU - Pachman, Lauren M.
AU - Green, Orville C.
AU - Lenz, Mary E.
AU - Hayford, Jennifer
AU - Thonar, Eugene J.M.A.
N1 - Funding Information: Keratan sulfate is a glycosaminoglycan; in man, most KS is present in cartilage proteoglycans, 1 but small amounts have been identified in blood.l, 2 Recent evidence indicates that this KS is almost exclusively derived from catabolism of cartilage proteoglycans.l-3 As a result, it has been postulated that the concentration of KS in the blood is directly proportional to the rate of degradation of cartilage proteoglycans.I, 2 Linear growth results from bone formation on a cartilage scaffold (endochondral ossification) and depends on adequate function of the hypothalamic-pituitary-somatomedin-insulin-like growth factor I axis and the genetic ability of cartilage to respond to these secretions. 4, 5 In the growing child, serum levels of KS are elevated, which is not unexpected because growing cartilages are constantly undergoing degradation and replacement by new bone formation. We previously reported that serum levels of keratan sulfate rise from low levels in infancy and reach a plateau by the age of 4 to 5 years. Serum concentrations of KS appear to remain high until age 12 years, when they rapidly decline toward the levels found in normal adult sera. Serum levels of KS in a growing child correlate with the individual child's age-adjusted percentile height. 6 In our investigation, we measured the serum concentrations of KS in two groups of children with short stature: one group with Constitutional delay of maturity and the other with growth hormone deficiency. In the latter group, we compared KS levels before and after treatment with growth Supported in part by grants from the Traders Foundation, the Marlene Apfelbaum Memorial Foundation, and the National Institutes of Health (N1H-NIAMS P60AM30692-01A1, NIH-AG04736, and NIH-1-P50-AR39239). Presented in part at the Society for Pediatric Research, April 1988. Submitted for publication Aug. 3, 1988; accepted Oct. 25, 1989. Reprint requests: Lauren M. Pachman, MD, Division of Immunology/Rheumatology, Children's Memorial Hospital, Chicago, IL 60614. 9/22/17749 hormone. The specific aims were to determine whether levels of KS were lower in children with short stature than in .' their age-, sex-, and race-matched control subjects, and to ascertain whether increased serum levels of KS paralleled increased growth velocity and increased somatomedin-IGF-I plasma levels after administration of growth hormone to growth hormone-deficient children.
PY - 1990/3
Y1 - 1990/3
UR - http://www.scopus.com/inward/record.url?scp=0025344173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025344173&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(05)82831-8
DO - 10.1016/S0022-3476(05)82831-8
M3 - Article
C2 - 2137876
AN - SCOPUS:0025344173
SN - 0022-3476
VL - 116
SP - 400
EP - 403
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -