@article{166ce3fb02d445f192e9dce1268f5900,
title = "Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients",
abstract = "The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global protein translation in human-induced pluripotent stem cell (hiPSC)-derived forebrain neural progenitor cells (NPCs) from four SZ patients relative to six unaffected controls. We report increased total protein levels and protein synthesis, together with two independent sets of quantitative mass spectrometry evidence indicating markedly increased levels of ribosomal and translation initiation and elongation factor proteins, in SZ hiPSC NPCs. We posit that perturbed levels of global protein synthesis in SZ hiPSC NPCs represent a novel post-transcriptional mechanism that might contribute to disease progression.",
author = "A. Topol and English, {J. A.} and E. Flaherty and P. Rajarajan and Hartley, {B. J.} and S. Gupta and F. Desland and S. Zhu and T. Goff and L. Friedman and J. Rapoport and D. Felsenfeld and G. Cagney and A. Mackay-Sim and Savas, {J. N.} and B. Aronow and G. Fang and B. Zhang and D. Cotter and Brennand, {K. J.}",
note = "Funding Information: Kristen J Brennand is a New York Stem Cell Foundation—Robertson Investigator. The Brennand Laboratory is supported by a Brain and Behavior Young Investigator Grant, National Institute of Health (NIH) grants R01 MH101454 and R01 MH106056 and the New York Stem Cell Foundation. The Cotter Laboratory is supported by Health Research Board Clinical Scientist Award. JN Savas is supported by NIH award R00DC013805-02; the Aronow laboratory by U19 MH194172. We thank the high-throughput screening core at Icahn School of Medicine at Mount Sinai, directed by Dan Felsenfeld, for critical assistance with high-content imaging and analysis. Publisher Copyright: {\textcopyright} 2015, Springer Nature. All rights reserved.",
year = "2015",
month = oct,
doi = "10.1038/TP.2015.118",
language = "English (US)",
volume = "5",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "10",
}
