Increased activation of the alternative complement pathway in sickle cell disease

David S. Chudwin*, Allen D. Korenblit, Mae Kingzette, Sharon Artrip, Sudha Rao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Complement proteins play an important role in host defenses against Streptococcus pneumoniae, a major cause of serious infections in sickle cell (SS) disease. Previous studies have suggested abnormalities of the alternative complement pathway in SS disease. We measured activation of the alternative pathway in sera from patients with SS disease utilizing an enzyme immunoassay which detects C3b,P complexes, derivative of the C3b,Bb,P alternative pathway convertase. In all, 89% of SS sera had elevated concentrations of C3b,P complexes, indicative of increased alternative pathway activation. Chronic activation of the alternative pathway may contribute to impaired host defense in SS patients.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalClinical Immunology and Immunopathology
Volume37
Issue number1
DOIs
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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