Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome

Laura C. Torchen, Ajay Kumar, Bhanu Kalra, Gopal Savjani, Ryan Sisk, Richard S. Legro, Andrea Dunaif*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective To investigate for differences in reproductive hormone levels in male relatives of women with polycystic ovary syndrome (PCOS). Design Cross-sectional study. Setting Academic medical center. Patient(s) Sixty-three fathers and 66 brothers of women with PCOS as well as two groups of control men of comparable age to fathers (older control, n = 30) and brothers (younger control, n = 58). Intervention(s) A single early morning fasting blood sample was obtained for the measurement of reproductive hormone levels. Main Outcome Measure(s) Testosterone, LH, FSH, antimüllerian hormone (AMH), inhibin B, estradiol (E2), and estrone (E1) levels were measured. Result(s) The AMH, LH, and FSH levels were significantly increased in male relatives compared with their respective control groups. The levels of E2, E1, T, and inhibin B did not differ between the groups. Conclusion(s) The AMH, LH, and FSH levels were increased in adult male relatives of women with PCOS, suggesting that they may have altered testicular function and changes in neuroendocrine regulation of gonadotropin secretion. These changes may reflect effects of PCOS susceptibility genes such as the recently mapped chromosome 11p14.1 locus in the region of the FSH B polypeptide gene.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalFertility and Sterility
Volume106
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Polycystic Ovary Syndrome
Hormones
Fathers
Siblings
Control Groups
Estrone
Gonadotropins
Genes
Testosterone
Estradiol
Fasting
Cross-Sectional Studies
Chromosomes
Outcome Assessment (Health Care)
Peptides
inhibin B

Keywords

  • Polycystic ovary syndrome
  • antimüllerian hormone
  • first degree relatives
  • gonadotropins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Torchen, Laura C. ; Kumar, Ajay ; Kalra, Bhanu ; Savjani, Gopal ; Sisk, Ryan ; Legro, Richard S. ; Dunaif, Andrea. / Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome. In: Fertility and Sterility. 2016 ; Vol. 106, No. 1. pp. 50-55.
@article{c8dd7764c6aa4aacb3ebe62267c963ec,
title = "Increased antim{\"u}llerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome",
abstract = "Objective To investigate for differences in reproductive hormone levels in male relatives of women with polycystic ovary syndrome (PCOS). Design Cross-sectional study. Setting Academic medical center. Patient(s) Sixty-three fathers and 66 brothers of women with PCOS as well as two groups of control men of comparable age to fathers (older control, n = 30) and brothers (younger control, n = 58). Intervention(s) A single early morning fasting blood sample was obtained for the measurement of reproductive hormone levels. Main Outcome Measure(s) Testosterone, LH, FSH, antim{\"u}llerian hormone (AMH), inhibin B, estradiol (E2), and estrone (E1) levels were measured. Result(s) The AMH, LH, and FSH levels were significantly increased in male relatives compared with their respective control groups. The levels of E2, E1, T, and inhibin B did not differ between the groups. Conclusion(s) The AMH, LH, and FSH levels were increased in adult male relatives of women with PCOS, suggesting that they may have altered testicular function and changes in neuroendocrine regulation of gonadotropin secretion. These changes may reflect effects of PCOS susceptibility genes such as the recently mapped chromosome 11p14.1 locus in the region of the FSH B polypeptide gene.",
keywords = "Polycystic ovary syndrome, antim{\"u}llerian hormone, first degree relatives, gonadotropins",
author = "Torchen, {Laura C.} and Ajay Kumar and Bhanu Kalra and Gopal Savjani and Ryan Sisk and Legro, {Richard S.} and Andrea Dunaif",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.fertnstert.2016.03.029",
language = "English (US)",
volume = "106",
pages = "50--55",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "1",

}

Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome. / Torchen, Laura C.; Kumar, Ajay; Kalra, Bhanu; Savjani, Gopal; Sisk, Ryan; Legro, Richard S.; Dunaif, Andrea.

In: Fertility and Sterility, Vol. 106, No. 1, 01.07.2016, p. 50-55.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome

AU - Torchen, Laura C.

AU - Kumar, Ajay

AU - Kalra, Bhanu

AU - Savjani, Gopal

AU - Sisk, Ryan

AU - Legro, Richard S.

AU - Dunaif, Andrea

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Objective To investigate for differences in reproductive hormone levels in male relatives of women with polycystic ovary syndrome (PCOS). Design Cross-sectional study. Setting Academic medical center. Patient(s) Sixty-three fathers and 66 brothers of women with PCOS as well as two groups of control men of comparable age to fathers (older control, n = 30) and brothers (younger control, n = 58). Intervention(s) A single early morning fasting blood sample was obtained for the measurement of reproductive hormone levels. Main Outcome Measure(s) Testosterone, LH, FSH, antimüllerian hormone (AMH), inhibin B, estradiol (E2), and estrone (E1) levels were measured. Result(s) The AMH, LH, and FSH levels were significantly increased in male relatives compared with their respective control groups. The levels of E2, E1, T, and inhibin B did not differ between the groups. Conclusion(s) The AMH, LH, and FSH levels were increased in adult male relatives of women with PCOS, suggesting that they may have altered testicular function and changes in neuroendocrine regulation of gonadotropin secretion. These changes may reflect effects of PCOS susceptibility genes such as the recently mapped chromosome 11p14.1 locus in the region of the FSH B polypeptide gene.

AB - Objective To investigate for differences in reproductive hormone levels in male relatives of women with polycystic ovary syndrome (PCOS). Design Cross-sectional study. Setting Academic medical center. Patient(s) Sixty-three fathers and 66 brothers of women with PCOS as well as two groups of control men of comparable age to fathers (older control, n = 30) and brothers (younger control, n = 58). Intervention(s) A single early morning fasting blood sample was obtained for the measurement of reproductive hormone levels. Main Outcome Measure(s) Testosterone, LH, FSH, antimüllerian hormone (AMH), inhibin B, estradiol (E2), and estrone (E1) levels were measured. Result(s) The AMH, LH, and FSH levels were significantly increased in male relatives compared with their respective control groups. The levels of E2, E1, T, and inhibin B did not differ between the groups. Conclusion(s) The AMH, LH, and FSH levels were increased in adult male relatives of women with PCOS, suggesting that they may have altered testicular function and changes in neuroendocrine regulation of gonadotropin secretion. These changes may reflect effects of PCOS susceptibility genes such as the recently mapped chromosome 11p14.1 locus in the region of the FSH B polypeptide gene.

KW - Polycystic ovary syndrome

KW - antimüllerian hormone

KW - first degree relatives

KW - gonadotropins

UR - http://www.scopus.com/inward/record.url?scp=84963579897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963579897&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2016.03.029

DO - 10.1016/j.fertnstert.2016.03.029

M3 - Article

C2 - 27042970

AN - SCOPUS:84963579897

VL - 106

SP - 50

EP - 55

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 1

ER -