Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults

Tamas Csipo, Agnes Lipecz, Peter Mukli, Dhay Bahadli, Osamah Abdulhussein, Cameron D. Owens, Stefano Tarantini, Rachel A. Hand, Valeriya Yabluchanska, J. Mikhail Kellawan, Farzaneh Sorond, Judith A. James, Anna Csiszar, Zoltan I. Ungvari, Andriy Yabluchanskiy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Understanding how the brain allocates resources to match the demands of active neurons under physiological conditions is critically important. Increased metabolic demands of active brain regions are matched with hemodynamic responses known as neurovascular coupling (NVC). Several methods that allow noninvasive assessment of brain activity in humans detect NVC and early detection of NVC impairment may serve as an early marker of cognitive impairment. Therefore, non-invasive NVC assessments may serve as a valuable tool to detect early signs of cognitive impairment and dementia. Working memory tasks are routinely employed in the evaluation of cognitive task-evoked NVC responses. However, recent attempts that utilized functional near-infrared spectroscopy (fNIRS) or transcranial Doppler sonography (TCD) while using a similar working memory paradigm did not provide convincing evidence for the correlation of the hemodynamic variables measured by these two methods. In the current study, we aimed to compare fNIRS and TCD in their performance of differentiating NVC responses evoked by different levels of working memory workload during the same working memory task used as cognitive stimulation. Fourteen healthy young individuals were recruited for this study and performed an n-back cognitive test during TCD and fNIRS monitoring. During TCD monitoring, the middle cerebral artery (MCA) flow was bilaterally increased during the task associated with greater cognitive effort. fNIRS alsodetected significantly increased activation during a more challenging task in the left dorsolateral prefrontal cortex (DLPFC), and in addition, widespread activation of the medial prefrontal cortex (mPFC) was also revealed. Robust changes in prefrontal cortex hemodynamics may explain the profound change in MCA blood flow during the same cognitive task. Overall, our data support our hypothesis that both TCD and fNIRS methods can discriminate NVC evoked by higher demand tasks compared to baseline or lower demand tasks.

Original languageEnglish (US)
Article numbere0250043
JournalPloS one
Volume16
Issue number5 May
DOIs
StatePublished - May 2021

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults'. Together they form a unique fingerprint.

Cite this