Increased detectability of plasma HIV-1 RNA after introduction of a new assay and altered specimen-processing procedures

Peter F. Rebeiro, Asghar Kheshti, Sally S. Bebawy, Samuel E. Stinnette, Husamettin Erdem, Yi Wei Tang, Timothy R. Sterling, Stephen P. Raffanti, Richard T. D'Aquila

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

After changes to assay and specimen-processing methods, plasma human immunodeficiency virus type 1 (HIV-1) RNA was frequently detectable in patients who previously had well-suppressed HIV-1 RNA levels. This artifact is attributable to shipping frozen plasma in primary plasma preparation tubes and is not caused by the HIV-1 RNA detection assay; it can be avoided by shipping plasma in a secondary tube.

Original languageEnglish (US)
Pages (from-to)1354-1357
Number of pages4
JournalClinical Infectious Diseases
Volume47
Issue number10
DOIs
StatePublished - Nov 15 2008

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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