Increased efficacy and toxicity of lidocaine in patients on beta-blockers

D. George Wyse*, Joyce Kellen, Yun Tam, Alfred W. Rademaker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The greatest differences in ventricular arrhythmias and adverse effects of lidocaine observed in this study were between patients on both lidocaine and a beta-adrenoceptor blocking agent and those on neither drug. Although free fractions of lidocaine and methylglycylxylidine tended to be higher in patients on beta-adrenoceptor blocking agents, this difference was not significant nor were any other differences in serum drug levels observed.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalInternational Journal of Cardiology
Issue number1
StatePublished - Oct 1988


  • Adverse drug effect
  • Beta-blocker
  • Drug interaction
  • Lidocaine
  • Myocardial infarction
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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