Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer

Xingqi Zhang*, Chi Huang Chen, Edmond Confino, Randall Barnes, Magdy Milad, Ralph R. Kazer

*Corresponding author for this work

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Objective: To examine possible relationships between endometrial thickness and treatment outcome after IVF and embryo transfer, and to explore the role of potential confounding factors that may influence such relationships. Design: Retrospective study. Setting: A university-affiliated clinical IVF center. Patient(s): Patients undergoing IVF-embryo transfer with their own oocytes. Intervention(s): None. Main Outcome Measure(s): Endometrial thickness was determined on the day of hCG administration, 2 days before oocyte retrieval. Clinical pregnancy was confirmed by ultrasound observation of fetal heart activity. Result(s): The study analyzed 897 IVF-embryo transfer cycles. Treatment outcome (clinical pregnancy) after IVF-embryo transfer was positively associated with increased endometrial thickness and peak E2 concentrations in serum, and negatively associated with advanced age. Endometrial thickness was dependent on peak E2 concentrations in serum, but was independent of patient age or duration of ovarian stimulation. Thin endometrium reduced PRs in relatively young patients (<38 years old), in patients who required more than 10 days of gonadotropin stimulation, or in patients whose embryo transfers consisted of poor quality embryos. Conclusion(s): Increased endometrial thickness was associated with improved treatment outcome, but this association was dependant on patient age, duration of ovarian stimulation, and embryo quality.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalFertility and Sterility
Volume83
Issue number2
DOIs
StatePublished - Jan 1 2005

Keywords

  • Embryo quality
  • Endometrial thickness
  • Patient age
  • Pregnancy rates

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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