Increased excitability of both principal neurons and interneurons during associative learning

M Matthew Oh, John F Disterhoft*

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

In this review, we highlight several studies indicating that the modulation of intrinsic neuronal excitability is key for successful memory formation. Specifically, we will focus our discussion on our hypothesis that the postburst afterhyperpolarization (a key regulator of intrinsic excitability) is an essential cellular mechanism used by both principal and inhibitory neurons to change their neuronal activity as memory is formed. In addition, we propose that these intrinsic excitability changes occur first in principal neurons, followed by changes in inhibitory neurons, thus maintaining the balance of network activity among neurons for successful encoding and readout of memory.

Original languageEnglish (US)
Pages (from-to)372-384
Number of pages13
JournalNeuroscientist
Volume21
Issue number4
DOIs
StatePublished - Aug 21 2015

Fingerprint

Interneurons
Learning
Neurons

Keywords

  • CREB
  • inhibitory interneurons
  • intrinsic excitability
  • memory
  • postburst afterhyperpolarization
  • pyramidal neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

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Increased excitability of both principal neurons and interneurons during associative learning. / Oh, M Matthew; Disterhoft, John F.

In: Neuroscientist, Vol. 21, No. 4, 21.08.2015, p. 372-384.

Research output: Contribution to journalReview article

TY - JOUR

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AU - Disterhoft, John F

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AB - In this review, we highlight several studies indicating that the modulation of intrinsic neuronal excitability is key for successful memory formation. Specifically, we will focus our discussion on our hypothesis that the postburst afterhyperpolarization (a key regulator of intrinsic excitability) is an essential cellular mechanism used by both principal and inhibitory neurons to change their neuronal activity as memory is formed. In addition, we propose that these intrinsic excitability changes occur first in principal neurons, followed by changes in inhibitory neurons, thus maintaining the balance of network activity among neurons for successful encoding and readout of memory.

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